HSP90 ORCHESTRATES TRANSCRIPTIONAL REGULATION BY HSF1 AND CELL WALL REMODELLING BY MAPK SIGNALLING DURING THERMAL ADAPTATION IN A PATHOGENIC YEAST.

Hsp90 orchestrates transcriptional regulation by Hsf1 and cell wall remodelling by MAPK signalling during thermal adaptation in a pathogenic yeast.

Thermal adaptation is essential in all organisms.In yeasts, the heat shock response is commanded by the heat shock transcription factor Hsf1.Here we have integrated unbiased genetic screens with directed molecular dissection to demonstrate that multiple signalling cascades contribute to thermal adaptation in the pathogenic yeast Candida albicans.We

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Allograft Interposition Bone Graft for First Metatarsal Phalangeal Arthrodesis: Salvage after Bone Loss and Shortening of the First Ray

Category: Bunion; Midfoot/Forefoot; Other Introduction/Purpose: Previous studies have demonstrated success in using autogenous bone graft for arthrodesis in patients with previously failed surgeries of the hallux.These patients have several causes for pain and dysfunction preoperatively, including shortened first ray, nonunions, and poor hallux ali

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Monitoring Spatiotemporal Expansion Dynamics of Short-Rotation Eucalyptus Plantations Over Large Scales Using Landsat Time-Series Data

Eucalyptus, valued for its rapid growth and economic potential, has been widely introduced in China to address timber demands while conserving natural forests.Precisely estimating the spatiotemporal expansion of short-rotation eucalyptus plantations is crucial for evaluating their ecological and social value and formulating effective sustainable fo

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